Human Hsc70 ELISA Kit
CAT.NO. : ARG81193
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概述
产品描述 | ARG81193 Human Hsc70 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human Hsc70 in cell lysates, serum and tissue lysates. |
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反应物种 | Hu |
应用 | ELISA |
靶点名称 | Hsc 70 |
偶联标记 | HRP |
偶联标记说明 | Substrate: TMB and read at 450 nm |
灵敏度 | 1.54 ng/ml |
样品类型 | Cell lysates, serum and tissue lysates. |
标准范围 | 2.34 - 150 ng/ml |
样本量 | 100 µl |
別名 | NIP71; HEL-33; HSPA10; LAP-1; HSC70; HSC71; LAP1; Lipopolysaccharide-associated protein 1; Heat shock 70 kDa protein 8; HSC54; HEL-S-72p; Heat shock cognate 71 kDa protein; HSP71; HSP73; LPS-associated protein 1 |
应用说明
检测时间 | 1.5 hours |
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属性
形式 | 96 well |
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存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
数据库连接 | |
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基因名称 | HSPA8 |
全名 | heat shock 70kDa protein 8 |
背景介绍 | This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
生物功能 | Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP. [UniProt] |
产品亮点 | Related products: Hsc70 antibodies; Hsc70 ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
翻译后修饰 | Acetylated. ISGylated. Trimethylation at Lys-561 reduces fibrillar SNCA binding. |
