Human HtrA2 / Omi ELISA Kit
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CAT.NO. : ARG83456
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Product Details
概述
| 产品描述 | ARG83456 Human HtrA2 / Omi ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human HtrA2 / Omi in Serum, plasma and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | HtrA2 / Omi |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 15 pg/ml |
| 样品类型 | Serum, plasma and cell culture supernatants. |
| 标准范围 | 31.2 - 2000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| 別名 | Serine protease HTRA2, mitochondrial; Serine proteinase OMI; Omi stress-regulated endoprotease; OMI; EC 3.4.21.108; PARK13; High temperature requirement protein A2; PRSS25; Serine protease 25; HtrA2 |
应用说明
| 检测时间 | 3.5 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 4°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O43464 Human Serine protease HTRA2, mitochondrial |
|---|---|
| 基因名称 | HTRA2 |
| 全名 | HtrA serine peptidase 2 |
| 背景介绍 | This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. [UniProt] |
| 细胞定位 | Mitochondrion intermembrane space_x000D_Mitochondrion membrane; Single-pass membrane protein. [UniProt] |
| 翻译后修饰 | Autoproteolytically activated. [UniProt] |
检测图片 (1)
ARG83456 Human HtrA2 / Omi ELISA Kit standard curve image
ARG83456 Human HtrA2 / Omi ELISA Kitresults of a typical standard run with optical density reading at 450 nm.
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