Human IFN alpha recombinant protein (Active) (His-tagged, N-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- Protein Full name:
- 生物活性:
- 活性说明:
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Brand:
CAT.NO. : ARG70385
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (N-ter) Active Human IFN alpha recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | IFN alpha |
| 物种 | Human |
| A.A. 序列 | Cys24 - Glu189 |
| 表达系统 | E. coli |
| Protein Full name | Interferon alpha-1/13 |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to inhibit IL-8 secretion in human PBMCs in the presence of LPS. The ED50 for this effect is |
| 別名 | IFNA1; Interferon Alpha 1; IFN-AlphaD; IFN-ALPHA IFNA13; IFNA@; IFL; IFN; Interferon Alpha-1/13; Interferon Alpha 1b; Interferon Alpha-D; IFN-Alpha-1/13; LeIF D; Interferon-Alpha1; IFN-Alpha 1b |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 8.0) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | IFNA1 |
|---|---|
| 全名 | Interferon Alpha 1 |
| 背景介绍 | This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. This cytokine is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia. |
| 生物功能 | Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. |
| 细胞定位 | Secreted |
| 翻译后修饰 | Disulfide bond |
检测图片 (1)
ARG70385 Human IFN alpha recombinant protein (Active) (His-tagged, N-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70385 Human IFN alpha recombinant protein (Active) (His-tagged, N-ter)
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