Human IgG4 Screen Nutritional 88 ELISA Kit
Key features and details
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- 偶联标记:
- 偶联标记说明:
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Brand:
CAT.NO. : ARG80822
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Product Details
概述
| 产品描述 | ARG80822 Human IgG4 Screen Nutritional 88 ELISA Kit has been designed for the quantification of specific antigen-related IgG4 antibodies in serum and plasma (EDTA, heparin). |
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| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | IgG4 Screen Nutritional 88 |
| 偶联标记 | AP |
| 偶联标记说明 | Substrate: PNPP and read at 405 nm |
| 灵敏度 | depending on allergen |
| 样品类型 | Serum and plasma (EDTA, heparin). |
| 标准范围 | 0.35 - 100 U/ml |
| 样本量 | 100 µl |
应用说明
| 检测时间 | 1 h, 30 min (37°C), 1 h (37°C/dark) |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 全名 | IgG4 Screen Nutritional 88 |
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| 背景介绍 | Incompatibility reactions against food may cause various symptoms in the human organism and this disturbance is manifested in the immune system by the formation of specific IgE, IgG or IgG4 antibodies. Statistics show that 60% of the population suffer from intolerances against at least one foodstuff, which may cause clinical symptoms or enhance them. Hints may be various and reach from skin irritations over digestive disorders up to migraine. With the diagnostic findings of unspecific discomfort, allergies or intolerances against food should be clarified. The theoretical basis for the determination of specific IgG or IgG4 for the diagnosis of food intolerances depends on the observation that some subclasses of IgG (mainly IgG4) are connected to the in vitro degranulation of basophilic cells and mastocytes and the activation of the complement cascade. It was also observed that high concentrations of circulating IgG were measured in atopic persons. Already early surveys showed that in persons with inflammatory reactions against food IgG but not IgE was detected. Significantly enhanced IgG and IgG4 titers were also found in patients with food intolerances. Skin tests are relatively poorly correlated to food allergies and are only significant in the presence of IgE related reactions. As additional diagnostic tools provocation and elimination diets are applied. These methods depend strongly on the motivation and compliance of the patient. Due to these constraints nowadays serological determinations of antibodies against various food panels are applied increasingly. The two reactions related with the immune system differ insofar as the IgE associated food allergy occurs within the next hour following the food intake, while IgG/IgG4 intolerances show a delayed reaction of 24 to 120 hours and persistent symptoms may arise. |
| 产品亮点 | Related products: IgG4 ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 研究领域 | Immune System kit |
检测图片 (1)
ARG80822 Human IgG4 Screen Nutritional 88 ELISA Kit example of standard curve image
ARG80822 Human IgG4 Screen Nutritional 88 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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