Human IL1 Receptor II recombinant protein (ECD) (His-tagged, C-ter)
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CAT.NO. : ARG70303
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Product Details
概述
| 产品描述 | HEK293 expressed, His-tagged (C-ter) Human IL1 Receptor II recombinant protein (ECD). |
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| 反应物种 | Hu |
| 应用 | Binding, SDS-PAGE |
| 靶点名称 | IL1 Receptor II (ECD) |
| 物种 | Human |
| A.A. 序列 | Met1 - Glu343 of Human IL1 Receptor II (NP_004624.1) with 6X His tag at the C-terminus. |
| 表达系统 | HEK293 |
| 別名 | IL-1 type II receptor; mIL-1RII; CDw121b; Interleukin-1 receptor type II; CD antigen CD121b; CD121b; Interleukin-1 receptor type 2; IL1R2c; sIL-1R2; IL1RB; Interleukin-1 receptor beta; sIL-1RII; IL-1R-2; IL-1RT2; IL-1RT-2; CD121 antigen-like family member B; mIL-1R2; IL-1R-beta |
应用说明
| 应用说明 | Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL1R2 at 2µg/ml (100µl/well) can bind Human IL1RA with a linear range of 31.25-43.5 ng/ml. |
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属性
| 形式 | Powder |
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| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL1R2 |
| 全名 | interleukin 1 receptor, type II |
| 背景介绍 | The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012] |
| 生物功能 | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. [UniProt] |
| 细胞定位 | Isoform Short: Secreted. Isoform Long: Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 45 kDa |
| 翻译后修饰 | A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported. [UniProt] |
检测图片 (1)
ARG70303 Human IL1 Receptor II recombinant protein (ECD) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70303 Human IL1 Receptor II recombinant protein (ECD) (His-tagged, C-ter).
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