Human IL23A / IL23 p19 recombinant protein (Active) (His-tagged, N-ter)
Key features and details
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- A.A. 序列:
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Brand:
CAT.NO. : ARG70067
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (N-ter) Active Human IL23A / IL23 p19 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | IL23A / IL23 p19 |
| 物种 | Human |
| A.A. 序列 | Arg20 - Pro189 |
| 表达系统 | E. coli |
| 生物活性 | Active |
| 活性说明 | Determinedd by its ability to induce IL-17 secretion in mouse splenocytes. The ED50 for this effect is |
| 別名 | IL-23A; IL-23; IL-23 subunit alpha; IL23P19; IL-23p19; Interleukin-23 subunit alpha; IL-23-A; P19; SGRF; Interleukin-23 subunit p19 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 8.0) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | IL23A |
|---|---|
| 全名 | interleukin 23, alpha subunit p19 |
| 背景介绍 | This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008] |
| 生物功能 | Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. [UniProt] |
| 细胞定位 | Secreted. Note=Secreted upon association with IL12B. [UniProt] |
检测图片 (1)
ARG70067 Human IL23A / IL23 p19 recombinant protein (Active) (His-tagged, N-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70067 Human IL23A / IL23 p19 recombinant protein (Active) (His-tagged, N-ter).
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