Human IL6R alpha recombinant protein (ECD) (His-tagged, C-ter)
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CAT.NO. : ARG70288
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Product Details
概述
| 产品描述 | HEK293 expressed, His-tagged (C-ter) Human IL6R alpha recombinant protein (ECD). |
|---|---|
| 反应物种 | Hu |
| 应用 | Binding, SDS-PAGE |
| 靶点名称 | IL6R alpha (ECD) |
| 物种 | Human |
| A.A. 序列 | Leu20 - Asp358 of Human IL6R alpha (NP_000556.1) with 6X His tag at the C-terminus. |
| 表达系统 | HEK293 |
| 別名 | IL-6R-alpha; CD126; IL6RA; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL6Q; CD antigen CD126; IL-6R 1; IL-6RA; gp80; IL6RQ; Interleukin-6 receptor subunit alpha; IL-6R-1; Membrane glycoprotein 80 |
应用说明
| 应用说明 | Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized Human IL6R at 1 ug/ml (100 µl/well) can bind Human IL-6 with a linear range of 2-15ng/ml. |
|---|
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 92% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P08887 Human Interleukin-6 receptor subunit alpha |
|---|---|
| 基因名称 | IL6R |
| 全名 | interleukin 6 receptor |
| 背景介绍 | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2011] |
| 生物功能 | Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal (PubMed:28265003). Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. [UniProt] |
| 细胞定位 | Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. [UniProt] |
| 预测分子量 | 52 kDa |
| 翻译后修饰 | A short soluble form may also be released from the membrane by proteolysis. [UniProt] |
检测图片 (1)
ARG70288 Human IL6R alpha recombinant protein (ECD) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70288 Human IL6R alpha recombinant protein (ECD) (His-tagged, C-ter).
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