Human IL7 recombinant protein (Active) (His-tagged, C-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- 生物活性:
- 活性说明:
- 別名:
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Brand:
CAT.NO. : ARG70050
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Active Human IL7 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | IL7 |
| 物种 | Human |
| A.A. 序列 | Asp26 - His177 |
| 表达系统 | E. coli |
| 生物活性 | Active |
| 活性说明 | Determinedd by its ability to induce PHA-activated human PBMCs proliferation. The ED50 for this effect is1 x 10^8 units/mg. |
| 別名 | IL-7; Interleukin-7 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 8.0) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | IL7 |
|---|---|
| 全名 | interleukin 7 |
| 背景介绍 | The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010] |
| 生物功能 | Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
检测图片 (1)
ARG70050 Human IL7 recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70050 Human IL7 recombinant protein (Active) (His-tagged, C-ter).
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