Human NCR3 / NKp30 recombinant protein (ECD) (Fc-His-tagged, C-ter)
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CAT.NO. : ARG70268
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Product Details
概述
| 产品描述 | HEK293 expressed, Fc-His-tagged (C-ter) Human NCR3 / NKp30 recombinant protein (ECD). |
|---|---|
| 反应物种 | Hu |
| 应用 | Binding, SDS-PAGE |
| 靶点名称 | NCR3 / NKp30 (ECD) |
| 物种 | Human |
| A.A. 序列 | Leu19 - Thr138 of Human NCR3 / NKp30 (NP_001138938.1) with an Fc-6X His tag at the C-terminus. |
| 表达系统 | HEK293 |
| 別名 | NK-p30; 1C7; CD antigen CD337; Activating natural killer receptor p30; NKp30; Natural cytotoxicity triggering receptor 3; MALS; LY117; Natural killer cell p30-related protein; CD337 |
应用说明
| 应用说明 | Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized recombinant Human B7-H6 at 2µg/ml (100 µl/well) can bind recombinant Human NCR3, the EC50 of Human NCR3 is 66.43 ng/ml. |
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属性
| 形式 | Powder |
|---|---|
| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O14931 Human Natural cytotoxicity triggering receptor 3 |
|---|---|
| 基因名称 | NCR3 |
| 全名 | natural cytotoxicity triggering receptor 3 |
| 背景介绍 | The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010] |
| 生物功能 | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 22 kDa |
检测图片 (1)
ARG70268 Human NCR3 / NKp30 recombinant protein (ECD) (Fc-His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70268 Human NCR3 / NKp30 recombinant protein (ECD) (Fc-His-tagged, C-ter).
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