Human PILRA ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 检测范围:
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Brand:
CAT.NO. : ARG83341
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Product Details
概述
| 产品描述 | ARG83341 Human PILRA ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human PILRA in serum, plasma and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | There is no detectable cross-reactivity with other relevant proteins. |
| 靶点名称 | PILRA |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 75 pg/ml |
| 检测范围 | 156 pg/ml - 10000 pg/ml |
| 样品类型 | Serum, Plasma and Cell culture supernatants. |
| 別名 | PILRA; Paired Immunoglobin Like Type 2 Receptor Alpha; FDF03; Paired Immunoglobulin-Like Type 2 Receptor Alpha; Inhibitory Receptor PILR-Alpha; Cell Surface Receptor FDF03; Paired Immunoglobin-Like Type 2 Receptor Alpha |
应用说明
| 检测时间 | ~ 5 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9UKJ1 Human Paired immunoglobulin-like type 2 receptor alpha |
|---|---|
| 基因名称 | PILRA |
| 全名 | Paired Immunoglobin Like Type 2 Receptor Alpha |
| 背景介绍 | Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. |
| 生物功能 | Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. |
| 细胞定位 | Cell membrane, Membrane, Secreted |
| 翻译后修饰 | Glycoprotein, Phosphoprotein |
检测图片 (1)
ARG83341 Human PILRA ELISA Kit standard curve image
ARG83341 Human PILRA ELISA Kitresults of a typical standard run with optical density reading at 450 nm.
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