Human pTau181 antibody pair (ARA972/ARA958)
Key features and details
- Reactivity:Human
- Application:Sandwich ELISA
- Gene name: MAPT
- Target:pTau181
-
Brand:
CAT.NO. : ARA6879
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Size:
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Product Details
Background
Plasma phosphorylated tau 181 (p-tau181) has emerged as a promising biomarker for Alzheimer's disease (AD) and related conditions. Studies show that elevated plasma p-tau181 levels are associated with increased amyloid-beta (Aβ) deposits across various brain regions in cognitively healthy adults. Furthermore, p-tau181 levels correlate with Aβ-positivity on positron emission tomography (PET), and they predict the conversion to dementia stage depending on renal function. However, p-tau181 does not appear to be directly linked to tau-PET burden.Additionally, plasma p-tau181 levels have been associated with cognitive decline in various populations, such as those with AD, mild cognitive impairment (MCI), and other neurodegenerative diseases. Moreover, p-tau181 levels have been identified as a noninvasive diagnostic and prognostic tool in clinical practice and trials.
Application
The pTau181 Matched Antibody Pair is expertly designed for immunoassay technologies and high-throughput ELISA platforms that require specifically labeled antibody pairs. These pairs can be customized with a variety of labels such as fluorophores, biotin, and beads. Compatible technologies include MSD, Luminex, Quanterix Simoa, Alpha Technology etc.
Component
| Products include | Catalog No. | Isotype | Quantity | Form |
|---|---|---|---|---|
| pTau181 Antibody (ARA6838) | KC-117 | Mouse IgG1 | 100μg | Liquid |
| Tau Antibody (ARA6807) | KC-240 | Mouse IgG2a | 100μg | Liquid |
| Recombinant Human p-Tau181 Protein | PC-002 | / | 20μg | Liquid |
Overview
|
Antibody Pair Specificity |
pTau181 |
|
Species Reactivity |
Human |
|
Protein Standard |
Recombinant Human p-Tau181 Protein [PC-002] |
|
Target Antigen |
Protein name: Microtubule-associated protein tau; Gene name: MAPT; UniProt Accession: P10636-8; Organism: Homo sapiens (Human) |
|
Cross Reactivity |
Not cross-react with Tau peptide or recombinant proteins without any phosphorylation site. |
Data
Sandwich ELISA
Microtiter wells were coated with ARA6838 at 2 µg/mL as the capture antibody. Recommbinant pTau181 protein (Cat #: PC-002) was used as the antigen. 500 ng/mL biotin conjugated Tau Antibody ARA6807 was used as the detection antibody.
Result: ARA6838 and ARA6807 can be used as a matched antibody pair to detect and quantify the concentration of Human pTau181 with high specificity.
Storage
Shipped at ambient temperature or with ice packs. Avoid repeated freeze-thaw cycles.
Upon receipt,
* 1 month when stored at 2 to 8 °C
* 12 months when aliquoted and stored at -20 °C or below
Upon receipt,
* 1 month when stored at 2 to 8 °C
* 12 months when aliquoted and stored at -20 °C or below
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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