Human RANKL ELISA Kit
Key features and details
- 反应物种:
- 应用:
- 靶点名称:
- 偶联标记:
- 灵敏度:
- 样品类型:
- 标准范围:
- 样本量:
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Brand:
CAT.NO. : ARG83796
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Product Details
概述
| 产品描述 | ARG83796 Human CD254 / RANKL ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human CD254 / RANKL in serum, plasma and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | CD254 / RANKL |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 31.25 pg/ml |
| 样品类型 | Serum, Plasma and Cell culture supernatants. |
| 标准范围 | 62.5 – 4000 pg/ml |
| 样本量 | 50 µl |
| 精确 | Intra-Assay CV: < 10% Inter-Assay CV: < 10% |
| 別名 | TRANCE; Osteoprotegerin ligand; CD254; sOdf; Receptor activator of nuclear factor kappa-B ligand; OPTB2; RANKL; OPGL; Tumor necrosis factor ligand superfamily member 11; hRANKL2; TNF-related activation-induced cytokine; Osteoclast differentiation factor; ODF; CD antigen CD254 |
应用说明
| 检测时间 | 4 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 4°C, -20°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O14788 Human Tumor necrosis factor ligand superfamily member 11 |
|---|---|
| 基因名称 | TNFSF11 |
| 全名 | tumor necrosis factor (ligand) superfamily, member 11 |
| 背景介绍 | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008] |
| 生物功能 | Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. [UniProt] |
检测图片
ARG83796 Human CD254 / RANKL ELISA Kit standard curve image
ARG83796 Human CD254 / RANKL ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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