Human Tau antibody pair (ARA6837/ARA958)
Key features and details
- Reactivity:Human
- Application:Sandwich ELISA
- Gene name: MAPT
- Target:Tau
-
Brand:
CAT.NO. : ARA6884
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Size:
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Product Details
Background
Human Tau is a protein that helps stabilize the internal skeleton of nerve cells (neurons) in the brain. This internal skeleton has a tube-like shape through which molecules are transported across the cell. Tau stabilizes the microtubules that make up this skeleton to help them function best. Tau is found mostly in the messenger cells of our brains, called neurons, and is predominantly expressed in the neurons of the cerebral cortex where it has the highest abundance. In Alzheimer's disease, an abnormal form of tau accumulates and begins sticking together in thread-like structures called neurofibrillary tangles. These tangles are not effectively disposed of through the cell’s usual ways of removing “trash.” The build-up damages the disrupting how neurons function. Tau tangles start in the brainstem, which connects the brain to the spinal cord. Elevated tau levels are observed in the brain decades before the onset of Alzheimer’s disease symptoms like memory loss.
Application
The Tau Matched Antibody Pair is expertly designed for immunoassay technologies and high-throughput ELISA platforms that require specifically labeled antibody pairs. These pairs can be customized with a variety of labels such as fluorophores, biotin, and beads. Compatible technologies include MSD, Luminex, Quanterix Simoa, Alpha Technology etc.
Component
| Products include | Catalog No. | Isotype | Quantity | Form |
|---|---|---|---|---|
| Tau Antibody (ARA6837) | KC-116 | Mouse IgG2b | 100μg | Liquid |
| Tau Antibody (ARA6807) | KC-240 | Mouse IgG2a | 100μg | Liquid |
| Recombinant Human Tau Protein | PP-11309 | / | 20μg | Liquid |
Overview
|
Antibody Pair Specificity |
Tau |
|
Species Reactivity |
Human |
|
Protein Standard |
Recombinant Human Tau Protein [PP-11309] |
|
Target Antigen |
Protein name: Microtubule-associated protein tau; Gene name: MAPT; UniProt Accession: P10636-8; Organism: Homo sapiens (Human) |
|
Cross Reactivity |
Not Tested |
Data
Microtiter wells were coated with ARA6837 at 2 µg/mL as the capture antibody. Recommbinant Tau protein (Cat #: PP-11309) was used as the antigen. 100 ng/mL biotin conjugated Tau Antibody (ARA6807) was used as the detection antibody.
Result: ARA6837 and ARA6807 can be used as a matched antibody pair to detect and quantify the concentration of Human Tau with high specificity.
Storage
Shipped at ambient temperature or with ice packs. Avoid repeated freeze-thaw cycles.
Upon receipt,
* 1 month when stored at 2 to 8 °C
* 12 months when aliquoted and stored at -20 °C or below
Upon receipt,
* 1 month when stored at 2 to 8 °C
* 12 months when aliquoted and stored at -20 °C or below
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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