Human TNFRSF11B / OPG ELISA Kit
Key features and details
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- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- Protein Full name:
- 灵敏度:
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Brand:
CAT.NO. : ARG83018
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Product Details
内含物
| 货号 | 内含物名称 | 包装 |
|---|---|---|
| ARG83018-01 | Antibody-coated microplate | 8 X 12 strips |
| ARG83018-02 | Standard (Lyophilized) | 3 X 2 ng/vials |
| ARG83018-03 | Standard diluent buffer | 20 ml |
| ARG83018-04 | Antibody conjugate concentrate | 1 vial |
| ARG83018-05 | Antibody diluent buffer | 16 ml |
| ARG83018-06 | HRP-Streptavidin concentrate | 1 vial |
| ARG83018-07 | HRP-Streptavidin diluent buffer | 16 ml |
| ARG83018-08 | 20X Wash buffer | 50 ml |
| ARG83018-09 | TMB substrate | 12 ml |
| ARG83018-10 | STOP solution | 12 ml |
| ARG83018-11 | Plate sealer | 4 strips |
概述
| 产品描述 | ARG83018 Human TNFRSF11B / OPG ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human TNFRSF11B / OPG in serum, plasma (heparin), ascites, urine and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | Not cross-reacts with: Human CD40, TNF RI, TNF RII |
| 靶点名称 | TNFRSF11B / OPG |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| Protein Full name | Tumor necrosis factor receptor superfamily member 11B |
| 灵敏度 | 31.25 pg/ml |
| 样品类型 | Serum, plasma (heparin), ascites, urine and cell culture supernatants. |
| 标准范围 | 62.5 - 4000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| 別名 | TNFRSF11B, TNF Receptor Superfamily Member 11b, OCIF, Osteoclastogenesis Inhibitory Factor, Osteoprotegerin, TR1, OPG, Tumor Necrosis Factor Receptor Superfamily, Member 11b, Tumor Necrosis Factor Receptor Superfamily Member 11B, PDB5 |
应用说明
| 检测时间 | ~ 4 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # O00300 Human Tumor necrosis factor receptor superfamily member 11B |
|---|---|
| 基因名称 | TNFRSF11B |
| 全名 | TNF Receptor Superfamily Member 11b |
| 背景介绍 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
| 生物功能 | Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 产品亮点 | Related products: Osteoprotegerin antibodies; Osteoprotegerin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 翻译后修饰 | Disulfide bond, Glycoprotein. [UniProt] |
检测图片 (1)
ARG83018 Human TNFRSF11B / OPG ELISA Kit standard curve image
ARG83018 Human TNFRSF11B / OPG ELISA Kit results of standard run with optical density reading at 450 nm
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