Human total IgE ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
- 标准范围:
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Brand:
CAT.NO. : ARG80774
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Product Details
概述
| 产品描述 | ARG80774 Human total IgE ELISA Kit has been designed for the quantification of total IgE antibodies in serum and plasma (EDTA, heparin). |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 靶点名称 | IgE |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm |
| 灵敏度 | 0.8 IU/ml |
| 样品类型 | Serum and plasma (EDTA, heparin). |
| 标准范围 | 5 - 1,000 IU/ml |
| 样本量 | 10 µl |
| 別名 | Immunoglobulin E |
应用说明
| 检测时间 | 30, 15 min |
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属性
| 形式 | 96 well |
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| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 全名 | Human total IgE |
|---|---|
| 背景介绍 | The existence of IgE in man as a unique class of immunoglobulins which are important in the mediation of the allergic response has been known for over twenty years. The mechanism of action involves an initial antigenic stimulation of immunocompetent B lymphocytes by a specific antigen, a process which induces the lymphocyte to respond by producing specific antibody of several classes. One class, reaginic or IgE antibody, becomes partially bound via its Fc portion to receptors on the surface of mast cells and basophilic leukocytes. Upon further stimulation by specific allergens, these cell-bound IgE molecules bind via their Fab portion to the allergen. This combination triggers the mast cells and basophilic leucocytes to release various vasoactive amines into the blood and the surrounding tissue. These substances cause smooth muscle constriction and lead ultimately to allergic conditions such as wheal and flare reactions, hives, dermatitis, rhinitis, hay fever, asthma and anaphylactic shock. IgE determinations are most valuable in the diagnostic assessment of patients with established or suspected allergic desease. In normal subjects, IgE values are related to age, with normal values peaking around 10 - 14 years. Infants and children with family history of atopic allergy are at increased risk of developing disease and constitute a prime population for screening. Studies have shown that conditions such as asthma, rhinitis, eczema, urticaria, dermatitis and some parasitic infections lead to increased IgE levels. Asthma, hay fever and atopic eczema patients may produce levels 3 - 10 times those of normal patients. |
| 产品亮点 | Related products: Human total IgE ELISA Kits; Related news: A designer cell-based histamine-specific human allergy profiler New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 研究领域 | Immune System kit |
检测图片 (1)
ARG80774 Human total IgE ELISA Kit standard curve image
ARG80774 Human total IgE ELISA Kit results of a typical standard run with optical density reading at 450nm.
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