Human Tpo / Thrombopoietin recombinant protein (His-tagged, N-ter)
Key features and details
- 产品描述:
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- 靶点名称:
- 物种:
- A.A. 序列:
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Brand:
CAT.NO. : ARG70139
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (N-ter) Human Tpo / Thrombopoietin recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | Tpo / Thrombopoietin |
| 物种 | Human |
| A.A. 序列 | Ser22 - Leu195 |
| 表达系统 | E. coli |
| 別名 | C-mpl ligand; Thrombopoietin; MPLLG; TPO; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand; MKCSF; THCYT1 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | THPO |
|---|---|
| 全名 | thrombopoietin |
| 背景介绍 | Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014] |
| 生物功能 | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
检测图片 (1)
ARG70139 Human Tpo / Thrombopoietin recombinant protein (His-tagged, N-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70139 Human Tpo / Thrombopoietin recombinant protein (His-tagged, N-ter).
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