Human ULBP2 ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
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Brand:
CAT.NO. : ARG81611
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Product Details
内含物
| 货号 | 内含物名称 | 包装 | 温度 |
|---|---|---|---|
| ARG81611-001 | Antibody-coated microplate | 8 X 12 strips | 4°C. Unused strips should be sealed tightly in the air-tight pouch. |
| ARG81611-002 | Standard | 2 X 10 ng/vial | 4°C |
| ARG81611-003 | Standard/Sample diluent | 30 ml (Ready to use) | 4°C |
| ARG81611-004 | Antibody conjugate concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG81611-005 | Antibody diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG81611-006 | HRP-Streptavidin concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG81611-007 | HRP-Streptavidin diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG81611-008 | 25X Wash buffer | 20 ml | 4°C |
| ARG81611-009 | TMB substrate | 10 ml (Ready to use) | 4°C (Protect from light) |
| ARG81611-010 | STOP solution | 10 ml (Ready to use) | 4°C |
| ARG81611-011 | Plate sealer | 4 strips | Room temperature |
概述
| 产品描述 | ARG81611 Human ULBP2 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human ULBP2 in serum, plasma (heparin, EDTA) and cell culture supernatants. |
|---|---|
| 反应物种 | Hu |
| 应用 | ELISA |
| 特异性 | There is no detectable cross-reactivity with other relevant proteins. |
| 靶点名称 | ULBP2 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 31.25 pg/ml |
| 样品类型 | Serum, plasma (heparin, EDTA) and cell culture supernatants. |
| 标准范围 | 62.5 - 4000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: 6.3% Inter-Assay CV: 7.1% |
| 別名 | N2DL-2; Retinoic acid early transcript 1H; RAET1H; NKG2DL2; UL16-binding protein 2; N2DL2; ALCAN-alpha; NKG2D ligand 2 |
应用说明
| 检测时间 | ~ 5 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ULBP2 |
| 全名 | UL16 binding protein 2 |
| 背景介绍 | This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015] |
| 生物功能 | Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. [UniProt] |
| 产品亮点 | Related products: ULBP antibodies; ULBP ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
检测图片 (1)
ARG81611 Human ULBP2 ELISA Kit standard curve image
ARG81611 Human ULBP2 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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