IFN gamma ELISA Antibody Duo

产品描述: IFN-gamma, also called Type II interferon, is a homodimeric glycoprotein containing approximately 21 to 24 kD subunits. The human IFN-gamma gene, situated on chromosome 12, contains three introns; the four exons code for a polypeptide of 166 amino acids, 20 of which constitute the signal peptide. In contrast to IFN-a and IFN-b synthesis, which can occur in any cell, production of IFN-gamma is a function of T cells and NK cells. All IFN-gamma inducers activate T cells either in a polyclonal (mitogens or antibodies) or in a clonally restricted, antigen-specific, manner. IFN-gamma is produced during infection by T cells of the cytotoxic/ suppressorphenotype CD8 and by a subtype of helper T cells, the Th1 cells. Th1 cells secrete IL-2, IL-3, TNF-beta and IFN-gamma, whereas Th2 cells mainly produceIL-3, IL-4, IL-5, and IL-10, but little or no IFN-gamma. IFN-g preferentially inhibits the proliferation of Th2 but not Th1 cells, indicating that the presenceof IFN-gamma during an immune response will result in the preferential proliferation of Th1 cells.Recommend usingCapture antibody: ARG65520, suggested dilution: 2-6 ug/mlDetection antibody: ARG65396, suggested dilution: 0.5-2 ug/mlRelated news:HMGB1 in inflammationInflammatory Cytokines
靶点名称: IFN gamma
別名: IFN gamma ELISA antibody; Biotin-conjugated IFN gamma antibody; IFN gamma antibody

CAT.NO. : ARG30234

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Size:

1 pair

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Product Details

内含物

货号	内含物名称	宿主克隆性	反应	应用	包装
ARG65520	anti-IFN gamma antibody [NIB42]	Mouse mAb	Hu	ELISA, FuncSt, IP, RIA	100 μg
ARG65396	anti-IFN gamma antibody [4S.B3] (Biotin)	Mouse mAb	Hu, NHuPrm	ELISA, FACS, ICC/IF, IHC-P, WB	50 μg

概述

产品描述	IFN-gamma, also called Type II interferon, is a homodimeric glycoprotein containing approximately 21 to 24 kD subunits. The human IFN-gamma gene, situated on chromosome 12, contains three introns; the four exons code for a polypeptide of 166 amino acids, 20 of which constitute the signal peptide. In contrast to IFN-a and IFN-b synthesis, which can occur in any cell, production of IFN-gamma is a function of T cells and NK cells. All IFN-gamma inducers activate T cells either in a polyclonal (mitogens or antibodies) or in a clonally restricted, antigen-specific, manner. IFN-gamma is produced during infection by T cells of the cytotoxic/ suppressor phenotype CD8 and by a subtype of helper T cells, the Th1 cells. Th1 cells secrete IL-2, IL-3, TNF-beta and IFN-gamma, whereas Th2 cells mainly produce IL-3, IL-4, IL-5, and IL-10, but little or no IFN-gamma. IFN-g preferentially inhibits the proliferation of Th2 but not Th1 cells, indicating that the presence of IFN-gamma during an immune response will result in the preferential proliferation of Th1 cells. Recommend using Capture antibody: ARG65520, suggested dilution: 2-6 ug/ml Detection antibody: ARG65396, suggested dilution: 0.5-2 ug/ml Related news: HMGB1 in inflammation Inflammatory Cytokines
靶点名称	IFN gamma
別名	IFN gamma ELISA antibody; Biotin-conjugated IFN gamma antibody; IFN gamma antibody

属性

存放说明	Store antibodies at 4°C or -20°C. Please refer to the each product datasheet for detail temperatures of the antibodies.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

全名	ELISA Antibody Duo for IFN gamma
背景介绍	This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia. [provided by RefSeq, Nov 2009]
生物功能	Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. [provided by Uniprot]
产品亮点	Related products: IFN gamma antibodies; IFN gamma ELISA Kits; IFN gamma Duos / Panels; IFN gamma recombinant proteins;
研究领域	Cancer antibody; Developmental Biology antibody; Immune System antibody; Signaling Transduction antibody
翻译后修饰	Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.

检测图片 (1)

ARG65396 anti-IFN gamma antibody [4S.B3] (Biotin) FACS image
Flow Cytometry: Human peripheral whole blood stained with ARG65396 anti-IFN gamma antibody [4S.B3] (Biotin).

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