IL-11RA Rabbit Monoclonal Antibody(ARB581)

Key features and details

Reactivity:Human
Application:IHC
Host:Rabbit
Clonality:Monoclonal
Target:IL-11RA

Brand:

CAT.NO. : ARB6873

RMB Please choose

Size:

1mL

Trail, Bulk size or Custom requests Please contact us

Product Details

Background

Interleukin-11 Receptor Alpha (IL-11RA) is a subunit of the functional receptor for the pleiotropic cytokine IL-11. It forms a signaling complex with glycoprotein 130 (gp130), activating downstream JAK/STAT, MAPK and PI3K pathways. Primarily expressed in epithelial, stromal, hematopoietic and neuronal cells, IL-11RA mediates critical biological functions including tissue regeneration (intestinal mucosa, liver, bone), hematopoietic support (megakaryopoiesis, platelet production) and embryonic development. Interleukin-11 Receptor Alpha (IL-11RA) holds emerging diagnostic and prognostic relevance in fibro-inflammatory diseases and epithelial cancers. Its overexpression in tissues and elevated soluble levels in serum correlate with pathological fibrosis (lung, liver, kidney), serving as a potential biomarker for disease severity and progression. In oncology, upregulated IL-11RA expression is linked to gastrointestinal cancers (colorectal, gastric), breast cancer and metastasis, where it promotes tumor-stroma crosstalk, chemoresistance and poor survival.

Application

Application	Dilution Ratio
IHC-P	1:100-1:200

Overview

Predicted Molecular Wt	45kDa
Species Cross-reactivity	Human
Applications	IHC-P
Purity	ProA affinity purified IgG
Form	Liquid
Swissprot ID	Q14266
Subcellular location	Cytoplasm and membrane
Recommended Method	Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes.
Immunogen	Synthetic peptide.
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%