IL-17RC Rabbit Polyclonal Antibody
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:WB
- Host:Rabbit
- Clonality:Polyclonal
- Target:IL-17RC
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Brand:
CAT.NO. : ARA6726
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Product Details
Background
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
Application
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Application |
Dilution Ratio |
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WB |
1:500 - 1:1000 |
Overview
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Immunogen |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IL-17RC. The exact sequence is proprietary |
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Purification Method |
The antibody was purified by immunogen affinity chromatography |
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Clonality |
Polyclonal |
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Product Form |
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide |
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Gene Name |
IL17RC |
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Synonyms |
Interleukin-17 receptor C; IL-17 receptor C; IL-17RC; Interleukin-17 receptor homolog; IL17Rhom; Interleukin-17 receptor-like protein; IL-17RL; ZcytoR14 |
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Gene ID (Human) |
84818; |
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Protein ID (Human) |
Q8NAC3; |
Data
Western blot analysis of IL-17RC expression in HEK293T (A), Hela (B), H1688 (C), mouse lung (D), rat lung (E) whole cell lysates. (Predicted band size: 86 kD; Observed band size: 70 kD)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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