IL-22 Rabbit Polyclonal Antibody
Key features and details
- Reactivity:Human
- Application:WB, IHC-P
- Host:Rabbit
- Clonality:Polyclonal
- lsotype:IgG
- Target:IL-22
-
Brand:
CAT.NO. : ARA6817
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Product Details
Background
IL-22 a member of a group of cytokines called the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. It shares use of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. IL-22 is produced by activated NK and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 is rapidly produced by splenic LTi-like cells and also produced by Th17 cells and likely plays a role in the coordinated response of both adaptive innate immune systems, autoimmunity and tissue regeneration. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
|
WB |
1:500 - 1:1000 |
Overview
|
Immunogen |
Recombinant protein of human IL-22. The exact sequence is proprietary. |
|
Purification Method |
The antibody was purified by immunogen affinity chromatography. |
|
Clone Type |
Polyclonal |
|
Product Form |
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
|
Gene Name |
IL22 |
|
Alternative Names |
ILTIF; ZCYTO18; Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF |
|
Gene ID (Human) |
50616; |
|
Gene ID (Mouse) |
50929; |
|
Protein ID (Human) |
Q9GZX6; |
|
Protein ID (Mouse) |
Q8JYY9; |
Data
Western blot analysis of IL-22 expression in mouse kidney (A) whole cell lysates. (Predicted band size: 20 kD; Observed band size: 18 kD)
Immunohistochemical staining of human brain tissue sections was performed using IL-22 Rabbit Polyclonal Antibody(ARA6817).
Storage
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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