IMP-3 Rabbit Monoclonal Antibody(ARB976)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6768
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Size:
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Product Details
Background
IMP-3 is RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. IMP-3 binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. IMP-3 binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells.
IMP-3 expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary, gonocytes of testis, growing oocytes, spermatogonia and semen. It also expressed in ovary, testis, brain, placenta, pancreatic cancer tissues, cervix adenocarcinoma, in testicular pancreatic and renal-cell carcinomas.
Multiple studies have found that IMP-3 is a marker of malignancy associated with increased tumor aggressiveness and decreased overall survival. It also can be used to distinguish pancreatic cancer from chronic sclerosing pancreatitis.
IMP-3 expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary, gonocytes of testis, growing oocytes, spermatogonia and semen. It also expressed in ovary, testis, brain, placenta, pancreatic cancer tissues, cervix adenocarcinoma, in testicular pancreatic and renal-cell carcinomas.
Multiple studies have found that IMP-3 is a marker of malignancy associated with increased tumor aggressiveness and decreased overall survival. It also can be used to distinguish pancreatic cancer from chronic sclerosing pancreatitis.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
64kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
O00425 |
|
Subcellular location |
Cytoplasm/Nucleus |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human pancreatic carcinoma tissue using IMP-3 Rabbit Monoclonal Antibody(ARB976)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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