Ksp-cadherin Rabbit Monoclonal Antibody(ARM516)
Key features and details
- Target:
- Clone ID:
- Host Species:
- Species Cross-reactivity:
- Applications:
- Dilution:
- Clonality:
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Brand:
CAT.NO. : ARM6806
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Ksp-cadherin, also known as kidney-specifc cadherin, is a cell adhesion molecule that is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells of the kidney, but not in glomerulus, renal interstitial cells, nor blood vessels. Ksp-cadherin has been identified as a potentially useful marker in differentiating between chromophobe renal-cell carcinoma and oncocytoma, as one study has found a membranous pattern of staining in 96% of 30 chromophobe carcinomas, and in only 6% of 31 oncocytomas. Cadherins have also been investigated in renal cell cancers, demonstrating that a loss of cadherins is potentially correlated to tumour differentiation and the presence of lymph node metastasis.
Application
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Application |
Dilution Ratio |
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IHC |
1:50 - 1:200 |
Overview
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Molecular Weight |
89,923 Da |
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Chromosome Location |
Chromosome: 16; NC_000016.9 (66942025..66952887, complement). Location: 16q22.1 |
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3D Structure |
ModBase 3D Structure for O75309 |
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Isotype |
IgG |
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Host |
Rabbit |
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Species Reactivity |
Human |
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Purity/Purification |
Purified |
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Form/Format |
Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide |
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Immunogen |
Recombinant Protein |
Data
Immunohistochemical staining of human kidney tissue using Ksp-cadherin Rabbit Monoclonal Antibody (ARM516).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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