MDR-1 Rabbit Monoclonal Antibody(ARB986)

Key features and details

Target: MDR-1
Clone ID: ARB986
Host: Rabbit
Molecular Weight: 141 kDa
Purity: ProA affinity purified IgG
Species Cross-reactivity: Human
Applications: IHC-P
Swissprot ID: P08183

Brand:

CAT.NO. : ARB6778

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Size:

1mL

Trail, Bulk size or Custom requests Please contact us

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Product Details

Background

ABCB1 belongs to the Mdr/Tap subfamily of the ATP-binding cassette transporter superfamily. Multidrug resistance 1 (MDR1) serves as an efflux pump for xenobiotic compounds with broad substrate specificity. MDR1 substrates include therapeutic agents such as actinomycin D, etoposide, imatinib, and doxorubicin, as well as endogenous molecules including β-amyloids, steroid hormones, lipids, phosphatide, cholesterol, and cytokines. Intracellular MDR1 has been detected in the ER, vesicles, and nuclear envelope, and has been associated with cell trafficking machinery. Other reported functions of MDR1 include viral resistance, cytokine trafficking, and lipid homeostasis in the peripheral and central nervous system.

MDR1 expressed in the plasma membrane of cells in the blood-brain, blood-cerebral spinal fluid, or blood-placenta barriers restricts the permeability of drugs into these organs from the apical or serosal side. MDR1 is also expressed in normal tissues with excretory function such as small intestine, liver, and kidney.

Research studies have shown that MDR1 reduces drug accumulation in cancer cells, allowing the development of drug resistance.

Application

Application	Dilution Ratio
IHC	1:100 - 1:200

Overview

Predicted Molecular Wt	141kDa
Species Cross-reactivity	Human
Applications	IHC-P
Purity	ProA affinity purified IgG
Form	Liquid
Swissprot ID	P08183
Subcellular location	Membrane
Recommended method	Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes
Storage Buffer	PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%