Mouse CD28 recombinant protein (ECD) (Fc-His-tagged, C-ter)
Key features and details
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CAT.NO. : ARG70329
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Product Details
概述
| 产品描述 | HEK293 expressed, Fc-His-tagged (C-ter) Mouse CD28 recombinant protein (ECD). |
|---|---|
| 反应物种 | Ms |
| 应用 | Binding, SDS-PAGE |
| 靶点名称 | CD28 (ECD) |
| 物种 | Mouse |
| A.A. 序列 | Asn20 - Lys149 of Mouse CD28 (NP_031668.3) with an Fc-6X His tag at the C-terminus. |
| 表达系统 | HEK293 |
| 別名 | Tp44; TP44; T-cell-specific surface glycoprotein CD28; CD antigen CD28 |
应用说明
| 应用说明 | Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse CD86 at 5µg/ml (100 µl/well) can bind Recombinant Mouse CD28 with a linear range of 1.5-6 µg/ml. |
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属性
| 形式 | Powder |
|---|---|
| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 97% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # P31041 Mouse T-cell-specific surface glycoprotein CD28 |
|---|---|
| 基因名称 | CD28 |
| 全名 | CD28 molecule |
| 背景介绍 | The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| 生物功能 | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. Isoform 3: Cell surface. [UniProt] |
| 预测分子量 | 25 kDa |
| 翻译后修饰 | CD40LG induces tyrosine phosphorylation of isoform 3. [UniProt] |
检测图片 (1)
ARG70329 Mouse CD28 recombinant protein (ECD) (Fc-His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70329 Mouse CD28 recombinant protein (ECD) (Fc-His-tagged, C-ter).
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