Mouse CD38 recombinant protein (His-tagged)
Key features and details
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CAT.NO. : ARG70497
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Product Details
概述
| 产品描述 | CHO expressed, His-tagged Mouse CD38 recombinant protein. |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | CD38 |
| 物种 | Mouse |
| A.A. 序列 | Leu45-Thr304 |
| 表达系统 | CHO |
| Protein Full name | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
| 別名 | CD38; CD38 Molecule; ADP-Ribosyl Cyclase 1; CADPR1; ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 1; 2'-Phospho-Cyclic-ADP-Ribose Transferase; 2'-Phospho-ADP-Ribosyl Cyclase; Cyclic ADP-Ribose Hydrolase 1; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2'-Phospho-ADP-Ribosyl Cyclase/2'-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase; Cluster Of Differentiation 38; CADPR Hydrolase 1; CD38 Antigen; EC 2.4.99.20; EC 3.2.2.-; EC 3.2.2.6; ADPRC1; T10 |
属性
| 形式 | Powder |
|---|---|
| 纯化 | >95% (by SDS-PAGE) |
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | CD38 |
|---|---|
| 全名 | CD38 Molecule |
| 背景介绍 | The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| 生物功能 | Synthesizes the Ca2+ mobilizer nicotinate-adenine dinucleotide phosphate, NAADP+, from 2'-phospho-cADPR and nicotinic acid, as well as from NADP+ and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP+, while preferentially cleaving NADP+ to cADPR and ADPRP rather than into NADDP+ (PubMed:16690024). Has cADPR hydrolase activity (PubMed:7961800, PubMed:8253715).[Uniprot] |
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