Mouse GDNF recombinant protein (His-tagged, C-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
- 物种:
- A.A. 序列:
- 表达系统:
- Protein Full name:
- 別名:
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Brand:
CAT.NO. : ARG70458
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Mouse GDNF recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | GDNF |
| 物种 | Mouse |
| A.A. 序列 | Ser78 - Ile211 |
| 表达系统 | E. coli |
| Protein Full name | Glial cell line-derived neurotrophic factor |
| 別名 | GDNF; Glial Cell Derived Neurotrophic Factor; Astrocyte-Derived Trophic Factor; HFB1-GDNF; ATF1; ATF2 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >98% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | GDNF |
|---|---|
| 全名 | Glial Cell Derived Neurotrophic Factor |
| 背景介绍 | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. |
| 生物功能 | Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. |
| 细胞定位 | Secreted |
| 翻译后修饰 | Cleavage on pair of basic residues, Disulfide bond, Glycoprotein |
检测图片 (1)
ARG70458 Mouse GDNF recombinant protein (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70458 Mouse GDNF recombinant protein (His-tagged, C-ter)
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