Mouse IL21R recombinant protein (ECD) (His-tagged, C-ter)
Key features and details
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- 靶点名称:
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CAT.NO. : ARG70315
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Product Details
概述
| 产品描述 | HEK293 expressed, His-tagged (C-ter) Mouse IL21R recombinant protein (ECD). |
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| 反应物种 | Ms |
| 应用 | Binding, SDS-PAGE |
| 靶点名称 | IL21R (ECD) |
| 物种 | Mouse |
| A.A. 序列 | Cys20 - Pro236 of Mouse IL21R (NP_068687.1) with 6X His tag at the C-terminus. |
| 表达系统 | HEK293 |
| 別名 | Interleukin-21 receptor; Novel interleukin receptor; CD360; CD antigen CD360; NILR; IL-21R; IL-21 receptor |
应用说明
| 应用说明 | Binding activity test: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse IL21R at 2µg/ml (100µl/well) can bind Recombinant Human IL-21 with a linear range of 0.128-83.57 ng/ml. |
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属性
| 形式 | Powder |
|---|---|
| 纯化说明 | 0.22 µm filter sterilized. Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | > 97% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | Reconstitute to a concentration of 0.1 - 0.5 mg/ml in sterile distilled water. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C for up to one month, at 2-8°C for up to one week. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | IL21R |
| 全名 | interleukin 21 receptor |
| 背景介绍 | The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010] |
| 生物功能 | This is a receptor for interleukin-21. [UniProt] |
| 细胞定位 | Membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 59 kDa |
| 翻译后修饰 | C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame. [UniProt] |
检测图片 (1)
ARG70315 Mouse IL21R recombinant protein (ECD) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70315 Mouse IL21R recombinant protein (ECD) (His-tagged, C-ter).
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