Mouse IL24 recombinant protein (Active) (His-tagged, C-ter)
Key features and details
- 产品描述:
- 应用:
- 靶点名称:
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- A.A. 序列:
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- 活性说明:
- 別名:
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Brand:
CAT.NO. : ARG70174
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Product Details
概述
| 产品描述 | E. coli expressed, His-tagged (C-ter) Active Mouse IL24 recombinant protein |
|---|---|
| 应用 | SDS-PAGE |
| 靶点名称 | IL24 |
| 物种 | Mouse |
| A.A. 序列 | Gln27 - Leu181 |
| 表达系统 | E. coli |
| 生物活性 | Active |
| 活性说明 | Determined by its ability to induce proliferation in BaF3 cells transfected with human IL-20 R alpha and human IL-20 R beta. The ED50 for this effect is |
| 別名 | IL10B; Interleukin-24; Melanoma differentiation-associated gene 7 protein; MDA7; MDA-7; C49A; ST16; FISP; Suppression of tumorigenicity 16 protein; IL-24; MOB5 |
属性
| 形式 | Powder |
|---|---|
| 纯化说明 | Endotoxin level is less than 0.1 EU/µg of the protein, as determined by the LAL test. |
| 纯度 | >95% (by SDS-PAGE) |
| 缓冲液 | PBS (pH 7.4) |
| 复溶 | It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 200 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely. |
| 存放说明 | For long term, lyophilized protein should be stored at -20°C or -80°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | IL24 |
|---|---|
| 全名 | interleukin 24 |
| 背景介绍 | This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| 生物功能 | Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 翻译后修饰 | Ubiquitination at Lys-122 promotes proteasomal degradation. [UniProt] |
检测图片 (1)
ARG70174 Mouse IL24 recombinant protein (Active) (His-tagged, C-ter) SDS-PAGE image
SDS-PAGE analysis of ARG70174 Mouse IL24 recombinant protein (Active) (His-tagged, C-ter).
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