Mouse MEP1B / Meprin Beta ELISA Kit
Key features and details
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- 反应物种:
- 应用:
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- 偶联标记:
- 偶联标记说明:
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CAT.NO. : ARG83440
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Product Details
概述
| 产品描述 | ARG83440 Mouse MEP1B / Meprin Beta ELISA Kit is an Enzyme Immunoassay kit for the quantification of Mouse MEP1B / Meprin Beta in Serum, plasma and cell culture supernatants., Cell Lysates, Tissue Homogenates |
|---|---|
| 反应物种 | Ms |
| 应用 | ELISA |
| 靶点名称 | MEP1B / Meprin Beta |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 10 pg/ml |
| 样品类型 | Serum, plasma and cell culture supernatants., Cell Lysates, Tissue Homogenates |
| 标准范围 | 156 - 10000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: less than 10% Inter-Assay CV: less than 10% |
| 別名 | MEP1B; Meprin A Subunit Beta; N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Subunit Beta; PABA Peptide Hydrolase; Endopeptidase-2; Meprin A, Beta; PPH Beta; Meprin B; N-Benzoyl-L-Tyrosyl-P-Amino-Benzoic Acid Hydrolase Beta Subunit; EC 3.4.24.63 |
应用说明
| 检测时间 | 3.5 hours |
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属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 4°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | MEP1B |
| 全名 | Meprin A Subunit Beta |
| 背景介绍 | Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. |
| 生物功能 | Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. |
| 细胞定位 | Cell membrane, Membrane, Secreted |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Zymogen |
检测图片 (1)
ARG83440 Mouse MEP1B / Meprin Beta ELISA Kit standard curve image
ARG83440 Mouse MEP1B / Meprin Beta ELISA Kitresults of a typical standard run with optical density reading at 450 nm.
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