Mouse OLR1 / LOX1 ELISA Kit
Key features and details
- 产品描述:
- 反应物种:
- 应用:
- 特异性:
- 靶点名称:
- 偶联标记:
- 偶联标记说明:
- 灵敏度:
- 样品类型:
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Brand:
CAT.NO. : ARG81752
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Product Details
内含物
| 货号 | 内含物名称 | 包装 | 温度 |
|---|---|---|---|
| ARG81752-001 | Antibody-coated microplate | 8 X 12 strips | 4°C. Unused strips should be sealed tightly in the air-tight pouch. |
| ARG81752-002 | Standard | 2 X 10 ng/vial | 4°C |
| ARG81752-003 | Standard/Sample diluent | 30 ml (Ready to use) | 4°C |
| ARG81752-004 | Antibody conjugate concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG81752-005 | Antibody diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG81752-006 | HRP-Streptavidin concentrate (100X) | 1 vial (100 µl) | 4°C |
| ARG81752-007 | HRP-Streptavidin diluent buffer | 12 ml (Ready to use) | 4°C |
| ARG81752-008 | 25X Wash buffer | 20 ml | 4°C |
| ARG81752-009 | TMB substrate | 10 ml (Ready to use) | 4°C (Protect from light) |
| ARG81752-010 | STOP solution | 10 ml (Ready to use) | 4°C |
| ARG81752-011 | Plate sealer | 4 strips | Room temperature |
概述
| 产品描述 | ARG81752 Mouse OLR1 / LOX1 ELISA Kit is an Enzyme Immunoassay kit for the quantification of Mouse OLR1 / LOX1 in serum, plasma (heparin, EDTA) and cell culture supernatants. |
|---|---|
| 反应物种 | Ms |
| 应用 | ELISA |
| 特异性 | There is no detectable cross-reactivity with other relevant proteins. |
| 靶点名称 | OLR1 / LOX1 |
| 偶联标记 | HRP |
| 偶联标记说明 | Substrate: TMB and read at 450 nm. |
| 灵敏度 | 15.6 pg/ml |
| 样品类型 | Serum, plasma (heparin, EDTA) and cell culture supernatants. |
| 标准范围 | 31.2 - 2000 pg/ml |
| 样本量 | 100 µl |
| 精确 | Intra-Assay CV: 6.1%; Inter-Assay CV: 7.2% |
| 別名 | Lectin-like oxidized LDL receptor 1; Lectin-type oxidized LDL receptor 1; LOX-1; CLEC8A; SLOX1; LOXIN; hLOX-1; Oxidized low-density lipoprotein receptor 1; Lectin-like oxLDL receptor 1; C-type lectin domain family 8 member A; Ox-LDL receptor 1; LOX1; SCARE1 |
应用说明
| 检测时间 | ~ 5 hours |
|---|
属性
| 形式 | 96 well |
|---|---|
| 存放说明 | Store the kit at 2-8°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | Swiss-port # Q9EQ09 Mouse Oxidized low-density lipoprotein receptor 1 |
|---|---|
| 基因名称 | OLR1 |
| 全名 | oxidized low density lipoprotein (lectin-like) receptor 1 |
| 背景介绍 | This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010] |
| 生物功能 | Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. [UniProt] |
| 产品亮点 | Related products: OLR1 antibodies; OLR1 ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 翻译后修饰 | The intrachain disulfide-bonds prevent N-glycosylation at some sites. N-glycosylated. [UniProt] |
检测图片 (1)
ARG81752 Mouse OLR1 / LOX1 ELISA Kit standard curve image
ARG81752 Mouse OLR1 / LOX1 ELISA Kit results of a typical standard run with optical density reading at 450 nm.
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