MRP1 Rabbit Monoclonal Antibody(ARA850)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:MRP1
-
Brand:
CAT.NO. : ARA6675
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the Mdr-1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an Mdr-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps expressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also mediates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. MRP6 protein is highly expressed in liver and kidney, whereas MRP4 and MRP5 are detected in various tissues yet at much lower levels of expression.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:50 - 1:200 |
Overview
|
Immunogen |
Synthetic peptide within Human MRP1 aa 1482-1531 / 1531 |
|
Species Reactivity |
Human |
|
Molecular Weight |
Predicted band size: 172 kDa |
|
Positive Control |
A549 cell lysate, HepG2 cell lysate, A549, human pancreas tissue, human tonsil tissue |
|
Conjugation |
unconjugated |
|
RRID |
AB_3070503 |
|
Form |
Liquid |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical analysis of paraffin-embedded human pancreas tissue using MRP1 Rabbit Monoclonal Antibody(ARA850).
Immunohistochemical analysis of paraffin-embedded human tonsil tissue using MRP1 Rabbit Monoclonal Antibody(ARA850).
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
