MSH6 Rabbit Monoclonal Antibody(ARA724)

Key features and details

Reactivity:Human
Application:WB, IHC
Host:Rabbit
Clonality:Monoclonal
Target:MSH6

Brand:

CAT.NO. : ARA6511

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Size:

1mL

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Product Details

Background

MSH6 is a mismatch repair protein which is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been suggested that the deficiencies in DNA mismatch repair protein(s) can be seen in some malignancies such as hereditary nonpolyposis colorectal cancer (HNPCC) and endometrial cancer. MSH6 expressed in all proliferating cells participate in repair of base-base mismatch, that occur during DNA replication. Loss of MSH6 expression leads to an accumulation of DNA replication errors in the proliferating cells, particularly in areas of the genome with short repetitive nucleotide sequences, a phenomenon known as microsatellite instability (MSI). MSH6 always used as panel with MLH1, MSH2, PMS2, and may be useful to aid in identifying the most probable gene responsible for the MSI.

Application

Application	Dilution Ratio
WB	1:200-1:1000
IHC-P	1:200-1:1000

Overview

Antibody Type	Recombinant Rabbit monoclonal Antibody
Immunogen	Synthetic peptide within Human MSH6 aa 350-450 (internal sequence).
Species Reactivity	Human, Mouse, Rat
Validated Applications	WB, IHC-P, IF-Cell, IF-Tissue
Molecular Weight	Predicted band size: 153 kDa
Positive Control	A549 cell lysate, HepG2 cell lysate, human tonsil tissue, human colon carcinoma tissue, human stomach carcinoma tissue, mouse small intestine tissue.
Conjugation	unconjugated
RRID	AB_3072286
Form	Liquid
Storage Buffer	PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype	IgG
Purification Method	Protein A affinity purified.