NeuroD1 Rabbit Monoclonal Antibody(ARA889)
Key features and details
- Reactivity:Human, Mouse, Rat
- Application:IHC
- Host:Rabbit
- Clonality:Monoclonal
- Target:NeuroD1
-
Brand:
CAT.NO. : ARA6716
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
The basic helix-loop-helix (bHLH) proteins are transcription factors that are required for several aspects of development, including cell type determination, terminal differentiation and sex determination. The HLH domain is required for dimerization, while the basic region makes specific contacts with DNA. Members of the myogenic determination family, MyoD, myf5, myogenin and MRF4, all have bHLH domains. These proteins heterodimerize with members of the E protein family and initiate myogenesis. Neuro D has been identified as a bHLH transcription factor functioning in neurogenic differentiation. Neuro D is expressed transiently in a subset of neurons in the central and peripheral nervous systems at the time of their terminal differentiation into mature neurons. Moreover, ectopic expression of Neuro D in Xenopus embryos induces premature differentiation of neuronal precursors and Neuro D can convert presumptive epidermal cells into neurons.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:200-1:500 |
Overview
|
Antibody Type |
Recombinant Rabbit monoclonal Antibody |
|
Immunogen |
Synthetic peptide within Human NeuroD1 aa 1-44 / 356 |
|
Species Reactivity |
Human, Mouse, Rat (Predicted: Cynomolgus monkey, Pig) |
|
Validated Applications |
WB, IP, IHC-P, IHC-Fr |
|
Molecular Weight |
Predicted band size: 40 kDa |
|
Positive Control |
Mouse cerebellum tissue, rat brain tissue, rat cerebellum tissue, Mouse cerebellum (P7) tissue lysate, Mouse cerebellum tissue lysate, Rat cerebellum tissue lysate |
|
Conjugation |
unconjugated |
|
RRID |
AB_3070428 |
|
Form |
Liquid |
|
Concentration |
1μg/ul |
|
Storage Buffer |
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol, Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue with NeuroD1 Rabbit Monoclonal Antibody(ARA889)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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