Neurofilament Mouse Monoclonal Antibody(ARB505)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
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Brand:
CAT.NO. : ARB6797
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Product Details
Background
Neurofilaments are the major intermediate filaments found in neurons and consist of light (NFL), medium (NFM), and heavy (NFH) subunits. Similar in structure to other intermediate filament proteins, neurofilaments have a globular amino-terminal head, a central α-helical rod domain, and a carboxy-terminal tail. A heterotetrameric unit (NFL-NFM and NFL-NFH) forms a protofilament, with eight protofilaments comprising the typical 10 nm intermediate filament.
Research studies have shown neurofilament accumulations in many human neurological disorders including Parkinson’s disease (in Lewy bodies along with α-synuclein), Alzheimer’s disease, Charcot-Marie-Tooth disease, and Amyotrophic Lateral Sclerosis (ALS).
Neurofilament antibody mainly stains neurons in tissue sections of brain and other tissues. Neurofilament has been shown to react with neuroblastomas, gangliomas, pheochromocytomas, Merkel cell tumors and carcinoid tumors.
Research studies have shown neurofilament accumulations in many human neurological disorders including Parkinson’s disease (in Lewy bodies along with α-synuclein), Alzheimer’s disease, Charcot-Marie-Tooth disease, and Amyotrophic Lateral Sclerosis (ALS).
Neurofilament antibody mainly stains neurons in tissue sections of brain and other tissues. Neurofilament has been shown to react with neuroblastomas, gangliomas, pheochromocytomas, Merkel cell tumors and carcinoid tumors.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
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Predicted Molecular Wt |
102kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
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Swissprot ID |
P07197 |
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Subcellular location |
Cytoplasm |
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Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
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Immunogen |
Recombinant fragment within Human HB Sag was used as an immunogen. |
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Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
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Storage Conditions |
-25°C to -18°C |
Data
Immunohistochemical staining of human brain tissue using Neurofilament Mouse Monoclonal Antibody(ARB505)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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