Nitric Oxide Synthase Assay Kit
Key features and details
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- 反应物种:
- 应用:
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- 偶联标记:
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- 样本量:
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Brand:
CAT.NO. : ARG81188
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Product Details
概述
| 产品描述 | ARG81188 Nitric Oxide Synthase Assay Kit is a detection kit for the quantification of Nitric Oxide Synthase activity in serum, plasma, whole blood, cell culture media, tissue or cell lysates. |
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| 反应物种 | Hu, Ms, Rat, Mamm |
| 应用 | FuncSt |
| 靶点名称 | Nitric Oxide Synthase |
| 偶联标记 | Un-conjugated |
| 灵敏度 | 0.25 U/L |
| 样品类型 | Serum, plasma, whole blood, cell culture media, tissue or cell lysates. |
| 标准范围 | 0.25 - 25 U/L |
| 样本量 | 20 µl |
| 別名 | Constitutive NOS; NOS type III; Nitric oxide synthase, endothelial; Endothelial NOS; eNOS; EC-NOS; NOSIII; cNOS; EC 1.14.13.39; ECNOS |
应用说明
| 应用说明 | Please note that this kit does not include a microplate. |
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| 检测时间 | ~ 2 hour |
属性
| 形式 | Liquid |
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| 存放说明 | Store components at 4°C or -20°C. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | NOS3 |
| 全名 | nitric oxide synthase 3 (endothelial cell) |
| 背景介绍 | Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| 生物功能 | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1. [UniProt] |
| 翻译后修饰 | Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity (By similarity). Phosphorylation of Ser-114 by CDK5 reduces activity. |
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