NKX3.1 Rabbit Monoclonal Antibody(ARM637)

Key features and details

Target: NKX3.1
Clone ID: ARM637
Host: Rabbit
Species Cross-reactivity: Human
Applications: IHC
Dilution: 1:50-1:200
Clonality: Monoclonal

Brand:

CAT.NO. : ARM6928

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Size:

100uL

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Product Details

Background

NKX3.1, also known as BAPX2 or NKX3A, is a homeobox protein located mainly in the prostate epithelium, and is also present in testis, ureter, and pulmonary bronchial mucous glands. The protein functions as a negative regulator of epithelial cell growth in prostate tissue, and as an androgen-regulated, prostatic tumour suppressor. NKX3.1 is clinically indicated in the majority of primary prostatic adenocarcinomas, as well as invasive ductal carcinomas and invasive lobular carcinomas of the breast. Underexpression of NKX3.1 is typical of human prostate carcinomas and prostatic intraepithelial neoplasia, and negative staining with Anti-NKX3.1 is common in urothelial carcinoma. Anti-NKX3.1 can be useful as an aid to distinguish between high grade prostate adenocarcinoma and high grade infiltrating urothelial carcinoma. It is also useful for identifying metastatic tumours and, when used in combination with Anti-ERG, this antibody may be a superior aid for identifying tumours of prostatic origin.

Application

Application	Dilution Ratio
IHC	1:50 - 1:200

Overview

Molecular Weight	26,350 Da
Chromosome Location	Chromosome: 8; NC_000008.10 (23536206..23540450, complement). Location: 8p21.2
3D Structure	ModBase 3D Structure for Q99801
Isotype	IgG
Host	Rabbit
Species Reactivity	Human
Purity/Purification	Purified
Form/Format	Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Immunogen	Recombinant Protein