NM23 Mouse Monoclonal Antibody(ARA868)
Key features and details
- Reactivity:Human
- Application:IHC
- Host:Mouse
- Clonality:Monoclonal
- Target:NM23
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Brand:
CAT.NO. : ARA6694
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Product Details
Background
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Application
|
Application |
Dilution Ratio |
|
IHC-P |
1:1000 |
Overview
|
Antibody Type |
Recombinant Mouse Monoclonal Antibody |
|
Immunogen |
Synthetic peptide within Human NME1 aa 78-126 / 152 |
|
Species Reactivity |
Human, Mouse, Rat |
|
Validated Applications |
WB, IF-Cell, IHC-P, FC |
|
Molecular Weight |
Predicted band size: 17 kDa |
|
Positive Control |
MCF7 cell lysate, PC-3M cell lysate, HeLa cell lysate, HepG2 cell lysate, A549 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, rat brain tissue lysate, MCF7, human breast carcinoma tissue, human colon tissue, human lymphoma tissue, mouse kidney tissue, rat kidney tissue |
|
Conjugation |
unconjugated |
|
Form |
Liquid |
|
Concentration |
1μg/ul |
|
Storage Buffer |
PBS (pH7.4), 0.1% BSA, 40% Glycerol, Preservative: 0.05% Sodium Azide |
|
Isotype |
IgG1 |
|
Purification Method |
Protein A affinity purified |
Data
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue with NM23 Mouse Monoclonal Antibody(ARA868)
Immunohistochemical analysis of paraffin-embedded human colon tissue with NM23 Mouse Monoclonal Antibody(ARA868)
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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