NM23 Mouse Monoclonal Antibody(ARA868)

Key features and details

Reactivity:Human
Application:IHC
Host:Mouse
Clonality:Monoclonal
Target:NM23

Brand:

CAT.NO. : ARA6694

RMB Please choose

Size:

1mL

Trail, Bulk size or Custom requests Please contact us

*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。

Product Details

Background

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

Application

Application	Dilution Ratio
IHC-P	1:1000

Overview

Antibody Type	Recombinant Mouse Monoclonal Antibody
Immunogen	Synthetic peptide within Human NME1 aa 78-126 / 152
Species Reactivity	Human, Mouse, Rat
Validated Applications	WB, IF-Cell, IHC-P, FC
Molecular Weight	Predicted band size: 17 kDa
Positive Control	MCF7 cell lysate, PC-3M cell lysate, HeLa cell lysate, HepG2 cell lysate, A549 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, rat brain tissue lysate, MCF7, human breast carcinoma tissue, human colon tissue, human lymphoma tissue, mouse kidney tissue, rat kidney tissue
Conjugation	unconjugated
RRID	AB_3071909
Form	Liquid
Concentration	1μg/ul
Storage Buffer	PBS (pH7.4), 0.1% BSA, 40% Glycerol, Preservative: 0.05% Sodium Azide
Isotype	IgG1
Purification Method	Protein A affinity purified