p-RIPK1(S166) Rabbit Monoclonal Antibody(YJY-1-5)
Key features and details
- Reactivity:Mouse
- Application:WB, IHC, ICC/IF, IP
- Host:Rabbit
- Clonality:Monoclonal
- Target:p-RIPK1(S166)
-
Brand:
CAT.NO. : ARA6605
RMB Please choose
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Size:
Trail, Bulk size or Custom requests Please contact us
Product Details
Background
Receptor-interacting serine/threonine-protein kinase 1 is a serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. RIPK1 is phosphorylated at several sites within the kinase domain that are sensitive to Nec-1, including Ser14, Ser15, Ser161, and Ser166.
Application
|
Application |
Dilution Ratio |
|
WB |
1:1000 - 1:2000 |
|
IHC |
1:100 - 1:500 |
|
ICC/IF |
1:100 - 1:500 |
|
IP |
1:50 - 1:500 |
Overview
|
Predicted Molecular Weight |
75kDa |
|
Species Cross-reactivity |
Mouse (Species cross-reactivity determined by WB) |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
Q60855 |
|
Immunogen |
A synthetic phospho-peptide corresponding to residues surrounding serine 166 of Mouse RIPK1 |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA |
Data
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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