p16 Mouse Monoclonal Antibody(ARB515)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6807
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
*产品价格可能会有所调整，请以品牌方官网实时更新的价格为准，以确保准确性。
Product Details
Background
The progression of cells through the cell cycle is regulated by a family of protein kinases known as cyclin-dependent kinases (Cdks). The sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. Moreover, the gene encoding p16 INK4A exhibits a high frequency of homozygous deletions and point mutations in established human tumor cell lines.
p16 INK4A expression is commonly inhibited by lack of stress and is thought to promote cellular senescence. And p16 INK4A expression is a commonly used cellular marker of senescence.
p16 INK4A protein expression is normally altered in human cancer cells, and its high expression can be used as a predictive biomarker in cervical cancer cells.
p16 INK4A expression is commonly inhibited by lack of stress and is thought to promote cellular senescence. And p16 INK4A expression is a commonly used cellular marker of senescence.
p16 INK4A protein expression is normally altered in human cancer cells, and its high expression can be used as a predictive biomarker in cervical cancer cells.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
17kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProG affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
P42771 |
|
Subcellular location |
Nucleus |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Immunogen |
Full length recombinant p16 INK4A of human origin was used as an immunogen |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human cervical intraepithelial neoplasia tissue using p16 Mouse Monoclonal Antibody(ARB515)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
New Products
