pan-Cadherin Rabbit Monoclonal Antibody(ARB517)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6809
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Size:
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Product Details
Background
Cadherins are a superfamily of transmembrane glycoproteins that contain cadherin repeats of approximately 100 residues in their extracellular domain. Cadherins mediate calcium-dependent cell-cell adhesion and play critical roles in normal tissue development. The classic cadherin subfamily includes N-, P-, R- and E-cadherins, as well as about ten other members that are found in adherens junctions, a cellular structure near the apical surface of polarized epithelial cells.
Cadherins are expressed in a number of normal tissues, including the stomach, esophagus and kidney. Cadherins are expressed in various types of cancer tissues, including the breast cancer, cervical carcinoma and gastric cancer.
Investigators consider that E-cadherin is an active suppressor of invasion and growth of many epithelial cancers. Research studies indicate that cancer cells have upregulated expression of N-cadherin and downregulated expression of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. Investigators have also demonstrated that expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers
Cadherins are expressed in a number of normal tissues, including the stomach, esophagus and kidney. Cadherins are expressed in various types of cancer tissues, including the breast cancer, cervical carcinoma and gastric cancer.
Investigators consider that E-cadherin is an active suppressor of invasion and growth of many epithelial cancers. Research studies indicate that cancer cells have upregulated expression of N-cadherin and downregulated expression of E-cadherin. This change in cadherin expression is called the "cadherin switch". N-cadherin cooperates with the FGF receptor, leading to overexpression of MMP-9 and cellular invasion. Investigators have also demonstrated that expression of P-cadherin, which is normally present in epithelial cells, is also altered in ovarian and other human cancers
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
97kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
P12830/P19022/P22223/P55283 |
|
Subcellular location |
Membrane and Cytoplasmic |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human esophagus tissue using pan-Cadherin Rabbit Monoclonal Antibody(ARB517)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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