Pan-TRK Rabbit Monoclonal Antibody(ARB518)
Key features and details
- Target:
- Clone ID:
- Host:
- Molecular Weight:
- Purity:
- Species Cross-reactivity:
- Applications:
- Swissprot ID:
-
Brand:
CAT.NO. : ARB6810
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Size:
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Product Details
Background
pan-TRK: Full name of NTRK: Neurotrophic Receptor Kinase. NTRK gene includes three subtypes: NTRK1, NTRK2 and NTRK3, which are located on different chromosomes. The proteins encoded by NTRK are called TRK proteins, and NTRK1, NTRK2 and NTRK3 encode TRKA, TRKB and TRKC respectively. TRK protein is a type of receptor tyrosine kinase that contains the extracellular ligand - binding region, the transmembrane region, and the intracellular tyrosine kinase region. When TRK binds to the ligand, dimerization occurs, and intracellular tyrosine kinase phosphorylation, signaling downstream.
Three TRKs proteins are rarely expressed outside nervous tissues, but the activation of three TRK receptor structures by fusion of three genes is considered to be an oncogenic factor (oncogene) in the pancancerous species.
NTRK gene fusion mutation is caused by the fusion of NTRK gene family members (NTRK1, NTRK2 and NTRK3) with another unrelated gene (usually housekeeping gene). The encoded TRK fusion protein is in a structurally activated state, which triggers a continuous signal cascade reaction, drives the malignant proliferation of cells, and causes cancer.
Three TRKs proteins are rarely expressed outside nervous tissues, but the activation of three TRK receptor structures by fusion of three genes is considered to be an oncogenic factor (oncogene) in the pancancerous species.
NTRK gene fusion mutation is caused by the fusion of NTRK gene family members (NTRK1, NTRK2 and NTRK3) with another unrelated gene (usually housekeeping gene). The encoded TRK fusion protein is in a structurally activated state, which triggers a continuous signal cascade reaction, drives the malignant proliferation of cells, and causes cancer.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:200 |
Overview
|
Predicted Molecular Wt |
92kDa |
|
Species Cross-reactivity |
Human |
|
Applications |
IHC-P |
|
Purity |
ProA affinity purified IgG |
|
Form |
Liquid |
|
Swissprot ID |
Q16620 |
|
Subcellular location |
Cytoplasm |
|
Recommended Method |
Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18℃-25℃) for 30 minutes |
|
Immunogen |
Synthetic peptide corresponding to residues within aa350-450 of FOXP1 was used as an immunogen |
|
Storage Buffer |
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05% |
Data
Immunohistochemical staining of human brain tissue using Pan-TRK Rabbit Monoclonal Antibody(ARB518)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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