PAP Mouse Monoclonal Antibody(ARA918)

Key features and details

Reactivity:Human, Mouse,Rat
Application:IHC
Host:Mouse
Clonality:Monoclonal
Target:PAP

Brand:

CAT.NO. : ARA6753

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Size:

1mL

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Product Details

Background

Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels. Certain medications can cause temporary increases or decreases in acid phosphatase levels. Manipulation of the prostate gland through massage, biopsy or rectal exam before a test may increase the level. Its physiological function may be associated with the liquefaction process of semen.

Application

Application	Dilution Ratio
IHC	1:200-1:1000

Overview

Antibody Type	Mouse Monoclonal Antibody
Immunogen	Synthesized peptide derived from human PSAP aa ranges: 201-300
Species Reactivity	Human, Mouse, Rat
Validated Applications	WB, IHC
Molecular Weight	45 kDa
Positive Control	Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.
Conjugation	unconjugated
Form	Liquid
Concentration	1μg/μl
Storage Buffer	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification Method	Immunogen affinity purified