PD-L1 Rabbit Monoclonal Antibody(ARM880)
Key features and details
- Target:
- Clone ID:
- Host Species:
- Species Cross-reactivity:
- Applications:
- Dilution:
- Clonality:
-
Brand:
CAT.NO. : ARM6670
RMB Please choose
RMB Please choose
Size:
Trail, Bulk size or Custom requests Please contact us
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Product Details
Background
Programmed Death-Ligand 1 (PD-L1), CD274, or B7 Homolog 1 (B7-H1), is a transmembrane protein involved in suppressing the immune system and rendering tumour cells resistant to lysis through binding of the Programmed Death-1 (PD-1) receptor. Overexpression of PD-L1 may allow cancer cells to evade the actions of the host immune system. In renal cell carcinoma, upregulation of PD-L1 has been linked to increased tumour aggressiveness and risk of death. When considered in adjunct with CD8+ tumour-infiltrating lymphocyte density, expression levels of PD-L1 may be a useful predictor of multiple cancer types, including stage III non-small-cell lung cancer, hormone receptor negative breast cancer, and sentinel lymph node melanoma.
Application
|
Application |
Dilution Ratio |
|
IHC |
1:100 - 1:400 |
Overview
|
Molecular Weight |
20,454 Da |
|
Isotype |
IgG |
|
Host |
Rabbit |
|
Species Reactivity |
Human |
|
Form/Format |
Liquid |
|
Buffer |
Tris Buffer, ph7.4, 1% BSA, <0.1% NaN3 |
|
IHC Positive Control |
Tonsil, Lung Adenocarcinoma |
Data
Immunohistochemical staining of human lung tissue using PD-L1 Rabbit Monoclonal Antibody (ARM880)
Storage
Store at -20°C. Stable for one year from the date of shipment.
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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