phospho-ACACA (Ser1263) Rabbit Polyclonal Antibody
Key features and details
- Reactivity:Human
- Application:ELISA
- Host:Rabbit
- Clonality:Polyclonal
- lsotype:IgG
- Target Name:phospho-ACACA (Ser1263)
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Brand:
CAT.NO. : ARA1263
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Product Details
Background
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene
Application
ELISA 1:5000-10000
Mol Weight
265kD
UniProt
Q13085
Specificity
Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver
Immunogen
KLH conjugated synthesised phosphopeptide derived from human Acetyl Coenzyme A Carboxylase alpha around the phosphorylation site of Ser1263
Storage Condition
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
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