Phospho beta Catenin Antibody Panel (Total, pS33, pS37, pT41 / pS45)
Key features and details
- 产品描述:
- 靶点名称:
- 別名:
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Product Details
| 货号 | 内含物名称 | 宿主克隆性 | 反应 | 应用 | 包装 |
|---|---|---|---|---|---|
| ARG52651 | anti-beta Catenin antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-Fr, IHC-P, IP, WB | 250 μl |
| ARG51709 | anti-beta Catenin phospho (Ser33) antibody | Rabbit pAb | Hu, Ms, Rat | IHC-P, WB | 50 μl |
| ARG51710 | anti-beta Catenin phospho (Ser37) antibody | Rabbit pAb | Hu, Ms, Rat | IHC-P, WB | 50 μl |
| ARG51618 | anti-beta Catenin phospho (Thr41 / Ser45) antibody | Rabbit pAb | Hu, Ms, Rat | WB | 50 μl |
| ARG65351 | Goat anti-Rabbit IgG antibody (HRP) | Goat pAb | Rb | ELISA, IHC-P, WB | 50 μl |
| 产品描述 | β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Both Akt and PKA were shown to phosphorylate β-catenin at Ser552 and Ser675. Phosphorylation at Ser552 and Ser675 induces β-catenin accumulation in the nucleus and increases its transcriptional activity.This antibody panel investigates different processes through the phosphorylation on multiple site of β-Catenin. Cadigan, K.M. and Nusse, R. (1997) Genes Dev 11, 3286-305. Amit, S. et al. (2002) Genes Dev 16, 1066-76. Liu, C. et al. (2002) Cell 108, 837-47. Yanagawa, S. et al. (2002) EMBO J 21, 1733-42. Yost, C. et al. (1996) Genes Dev 10, 1443-54. Fang D et al. (2007) J Biol Chem 282, 11221–9. He, X.C. et al. (2007) Nat. Genet. 39, 189-198. |
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| 靶点名称 | beta Catenin |
| 別名 | Phospho beta Catenin antibody; beta Catenin phospho (Thr41 / Ser45) antibody; beta Catenin phospho (Ser33) antibody; beta Catenin phospho (Ser37) antibody; beta Catenin antibody |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
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| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 全名 | Antibody Panel for Phospho beta Catenin (Total, pS33, pS37, pT41/pS45) |
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| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Developmental Biology antibody; Immune System antibody; Neuroscience antibody; Signaling Transduction antibody |
ARG52651 anti-beta Catenin antibody WB image
Western blot: 30 µg of 1) 293T, 2) 3T3, and 3) Mouse liver lysate stained with ARG52651 anti-beta Catenin antibody at 1:500 dilution.
ARG51618 anti-beta Catenin phospho (Thr41/Ser45) antibody WB image
Western Blot: extracts from SW626 cells stained with anti-beta Catenin (phospho Thr41/Ser45) antibody ARG51618 (Lane 2) and the same antibody preincubated with blocking peptide (Lane1).
ARG51709 anti-beta Catenin phospho (Ser33) antibody WB image
Western Blot: extracts from MCF-7 cells untreated or treated with Calyculin A stained with anti-beta Catenin (phospho Ser33) antibody ARG51709.
ARG51710 anti-beta Catenin phospho (Ser37) antibody WB image
Western Blot: extracts from HT29 cells stained with anti-beta Catenin (phospho Ser37) antibody ARG51710 and the same antibody preincubated with blocking peptide .
ARG52651 anti-Catenin-beta antibody WB image
Western Blot: A431 stained with Catenin-beta antibody (ARG52651)
ARG51709 anti-beta Catenin phospho (Ser33) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-beta Catenin (phospho Ser33) antibody ARG51709 (left) or the same antibody preincubated with blocking peptide (right).
ARG51710 anti-beta Catenin phospho (Ser37) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-beta Catenin (phospho Ser37) antibody ARG51710 (left) or the same antibody preincubated with blocking peptide (right).
ARG52651 anti-Catenin-beta antibody IHC-P image
Immunohistochemistry: Human Breast Carcinoma stained with Catenin-beta antibody (ARG52651)
Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway
ARG52651: WB / Mouse
Narasin inhibits tumor metastasis and growth of ERα‑positive breast cancer cells by inactivation of the TGF‑β/SMAD3 and IL‑6/STAT3 signaling pathways
ARG52651: WB / Human
Ubiquitin specific peptidase 5 enhances STAT3 signaling and promotes migration and invasion in Pancreatic Cancer.
ARG52651: WB / Human
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