Phospho Integrin beta 3 Antibody Panel (Total, pY773, pY785)

Key features and details

  • 产品描述: Cells recognize and respond to their extracellular environment through transmembrane receptors such as integrins, which physically connect the extracellular matrix to the cytoskeleton. Integrins provide the basis for the assembly of intracellular signaling platforms that link to the cytoskeleton and influence nearly every aspect of cell physiology. The integrin beta 3 protein mediates platelet adhesion to immobilized fibrinogen. Adhesion to fibrinogen induced rapid phosphorylation of Integrin beta 3 on Tyr773 and Tyr785 residues, which was reduced by Nitrogen Oxide in a cGMP independent manner. Oberprieler et al. 2007. FEBS Lett 581(7) Legate and Fassler. J Cell Sci 122: 187-98
  • 靶点名称: Integrin beta 3
  • 別名: Phospho Integrin beta 3 antibody; CD61 / Integrin beta 3 phospho (Tyr773) antibody; CD61 / Integrin beta 3 phospho (Tyr785) antibody; CD61 / Integrin beta 3 antibody (N-term)
  • Brand:
CAT.NO. : ARG30230
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Product Details
内含物
货号内含物名称宿主克隆性反应应用包装
ARG51564anti-CD61 / Integrin beta 3 phospho (Tyr773) antibodyRabbit pAbHu, MsIHC-P, WB50 μl
ARG51763anti-CD61 / Integrin beta 3 phospho (Tyr785) antibodyRabbit pAbHu, MsWB50 μl
ARG54044anti-CD61 / Integrin beta 3 antibody (N-term)Mouse mAbHuWB50 μl
ARG65350Goat anti-Mouse IgG antibody (HRP)Goat pAbMsELISA, IHC-P, WB50 μl
ARG65351Goat anti-Rabbit IgG antibody (HRP)Goat pAbRbELISA, IHC-P, WB50 μl
概述
产品描述Cells recognize and respond to their extracellular environment through transmembrane receptors such as integrins, which physically connect the extracellular matrix to the cytoskeleton. Integrins provide the basis for the assembly of intracellular signaling platforms that link to the cytoskeleton and influence nearly every aspect of cell physiology. The integrin beta 3 protein mediates platelet adhesion to immobilized fibrinogen. Adhesion to fibrinogen induced rapid phosphorylation of Integrin beta 3 on Tyr773 and Tyr785 residues, which was reduced by Nitrogen Oxide in a cGMP independent manner. Oberprieler et al. 2007. FEBS Lett 581(7) Legate and Fassler. J Cell Sci 122: 187-98
靶点名称Integrin beta 3
別名Phospho Integrin beta 3 antibody; CD61 / Integrin beta 3 phospho (Tyr773) antibody; CD61 / Integrin beta 3 phospho (Tyr785) antibody; CD61 / Integrin beta 3 antibody (N-term)
属性
存放说明For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项For laboratory research only, not for drug, diagnostic or other use.
生物信息
全名Antibody Panel for Phospho Integrin beta 3 (Total, pY773, pY785)
研究领域Cancer antibody; Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody
检测图片 (4)
  • ARG54044 anti-CD61 / Integrin beta 3 antibody (N-term) WB image

    Western blot: 25 µg of Leukocyte lysate stained with ARG54044 anti-CD61 / Integrin beta 3 antibody (N-term) at 1:1000 dilution.

  • ARG51564 anti-Integrin beta 3 phospho (Tyr773) antibody WB image

    Western Blot: extracts from 293 cells stained with anti-Integrin beta 3 (phospho Tyr773) antibody ARG51564 and the same antibody preincubated with blocking peptide.

  • ARG51564 anti-Integrin beta 3 phospho (Tyr773) antibody IHC-P image

    Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-Integrin beta 3 (phospho Tyr773) antibody ARG51564 (left) or the same antibody preincubated with blocking peptide (right).

  • ARG51763 anti-Integrin beta 3 phospho (Tyr785) antibody WB image

    Western Blot: extracts from HUVEC cells stained with anti-Integrin beta 3 (phospho Tyr785) antibody ARG51763 and the same antibody preincubated with blocking peptide .

参考文献

KDF1 Promoted Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells through Activating STAT3 and AKT Pathway

ARG65350: WB / 

Yi-Qing Guo et al.
Biomedicines.,  (2023)

publication_link

 

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