Phospho IRS1 Antibody Duo (pS636, pS307)

产品描述: Insulin receptor substrate 1 (IRS-1) is a signalling adapter protein that is phosphorylated by insulin receptor tyrosine kinase. Mutations in IRS-1 are associated with type II diabetes and susceptibility to insulin resistance. IRS-1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to PI3K / Akt and Erk MAP kinase pathways. IRS-1 also plays important biological function for both metabolic and mitogenic pathways. IRS-1 could be phosphorylated by p70S6K, a downstream protein of Akt, at Ser-307, Ser-636, and Ser-1101 to insulin sensitivity. In addition, IRS-1 is also potentially phosphorylated by the PKCθ kinase at Ser307. ARG30040, ARG30041 and ARG30042 IRS-1 phospho-Duos, containing antibodies recognize total IRS-1 and phosphorylated IRS-1 at Ser307 or Ser636, and PKC theta (pS695). These Duos are designed for the IRS-1 related studies; insulin related signaling and IRS-1 regulation study.
靶点名称: IRS1
別名: Phospho IRS1 antibody; Phospho Insulin receptor substrate 1 antibody; IRS1 phospho (Ser636) antibody; IRS1 phospho (Ser307) antibody

CAT.NO. : ARG30040

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Size:

1 pair

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Product Details

内含物

货号	内含物名称	宿主克隆性	反应	应用	包装
ARG51720	anti-IRS1 phospho (Ser636) antibody	Rabbit pAb	Hu, Ms, Rat	IHC-P, WB	50 μl
ARG51725	anti-IRS1 phospho (Ser307) antibody	Rabbit pAb	Hu, Ms, Rat	IHC-P	50 μl

概述

产品描述	Insulin receptor substrate 1 (IRS-1) is a signalling adapter protein that is phosphorylated by insulin receptor tyrosine kinase. Mutations in IRS-1 are associated with type II diabetes and susceptibility to insulin resistance. IRS-1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to PI3K / Akt and Erk MAP kinase pathways. IRS-1 also plays important biological function for both metabolic and mitogenic pathways. IRS-1 could be phosphorylated by p70S6K, a downstream protein of Akt, at Ser-307, Ser-636, and Ser-1101 to insulin sensitivity. In addition, IRS-1 is also potentially phosphorylated by the PKCθ kinase at Ser307. ARG30040, ARG30041 and ARG30042 IRS-1 phospho-Duos, containing antibodies recognize total IRS-1 and phosphorylated IRS-1 at Ser307 or Ser636, and PKC theta (pS695). These Duos are designed for the IRS-1 related studies; insulin related signaling and IRS-1 regulation study.
靶点名称	IRS1
別名	Phospho IRS1 antibody; Phospho Insulin receptor substrate 1 antibody; IRS1 phospho (Ser636) antibody; IRS1 phospho (Ser307) antibody

属性

存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

全名	Phospho Insulin receptor substrate 1 (IRS1) Antibody Duo (pS636, pS307)
研究领域	Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody

检测图片 (3)

ARG51720 anti-IRS-1 phospho (Ser636) antibody WB image
Western Blot: extracts from 3T3 cells untreated or treated with Insulin stained with anti-IRS-1 (phospho Ser636) antibody ARG51720.
ARG51720 anti-IRS-1 phospho (Ser636) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-IRS-1 (phospho Ser636) antibody ARG51720 (left) or the same antibody preincubated with blocking peptide (right).
ARG51725 anti-IRS-1 phospho (Ser307) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue, stained with anti-IRS-1 (phospho Ser307) antibody ARG51725).

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