Phospho IRS1 Antibody Duo (Total, pS636)
Key features and details
- 产品描述:
- 靶点名称:
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Product Details
| 货号 | 内含物名称 | 宿主克隆性 | 反应 | 应用 | 包装 |
|---|---|---|---|---|---|
| ARG51720 | anti-IRS1 phospho (Ser636) antibody | Rabbit pAb | Hu, Ms, Rat | IHC-P, WB | 50 μl |
| ARG51203 | anti-IRS1 antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| 产品描述 | Insulin receptor substrate 1 (IRS-1) is a signalling adapter protein that is phosphorylated by insulin receptor tyrosine kinase. Mutations in IRS-1 are associated with type II diabetes and susceptibility to insulin resistance.IRS-1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to PI3K / Akt and Erk MAP kinase pathways. IRS-1 also plays important biological function for both metabolic and mitogenic pathways.IRS-1 could be phosphorylated by p70S6K, a downstream protein of Akt, at Ser-307, Ser-636, and Ser-1101 to insulin sensitivity. In addition, IRS-1 is also potentially phosphorylated by the PKCθ kinase at Ser307.ARG30040, ARG30041 and ARG30042 IRS-1 phospho-Duos, containing antibodies recognize total IRS-1 and phosphorylated IRS-1 at Ser307 or Ser636, and PKC theta (pS695). These Duos are designed for the IRS-1 related studies; insulin related signaling and IRS-1 regulation study. |
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| 靶点名称 | IRS1 |
| 別名 | Phospho IRS1 antibody; Phospho Insulin receptor substrate 1 antibody; IRS1 antibody; IRS1 phospho (Ser636) antibody |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
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| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
| 全名 | Phospho Insulin receptor substrate 1 (IRS1) Antibody Duo (Total, pS636) |
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| 研究领域 | Cancer antibody; Cell Biology and Cellular Response antibody; Controls and Markers antibody; Metabolism antibody; Neuroscience antibody; Signaling Transduction antibody |
ARG51203 anti-IRS1 antibody WB image
Western blot: 30 µg of A549 and HepG2 cell line lysate stained with ARG51203 anti-IRS1 antibody at 1:500 dilution.
ARG51203 anti-IRS-1 antibody WB image
Western blot: 30 μg of 1) A549 and 2) HepG2 cell line lysate stained with ARG51203 anti-IRS-1 antibody at 1:500 dilution.
ARG51720 anti-IRS-1 phospho (Ser636) antibody WB image
Western Blot: extracts from 3T3 cells untreated or treated with Insulin stained with anti-IRS-1 (phospho Ser636) antibody ARG51720.
ARG51203 anti-IRS-1 antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-IRS-1 antibody ARG51203 (left) or the same antibody preincubated with blocking peptide (right).
ARG51203 anti-IRS-1 antibody ICC/IF image
Immunofluorescence: methanol-fixed HeLa cells stained with anti-IRS-1 antibody ARG51203.
ARG51720 anti-IRS-1 phospho (Ser636) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-IRS-1 (phospho Ser636) antibody ARG51720 (left) or the same antibody preincubated with blocking peptide (right).
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