Phospho Myc Antibody Duo (pS62, pS58)

产品描述: c-Myc is a multifunctional nuclear phosphoprotein that plays as a transcription factor to involve in controlling many cellular functions, including cell proliferation, cell growth, and cell differentiation, as well as pathways that regulate genome stability and cell death. Mutations, overexpression, rearrangement and translocation of c-myc have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. Phosphorylation of c-Myc at Ser62 by ERK or CDK kinases transiently increases c-Myc stability; however, phosphorylation of c-Myc at Thr58 by GSK3β triggers dephosphorylation of Ser62 by protein phosphatase 2A (PP2A), it lead to c-Myc ubiquitination by the SCF-Fbw7 E3 ligase and proteasomal degradation. Thus the phosphor-Ser62/Thr58 ratio of c-Myc is one of the important indexes in c-Myc activity and stability study.[PMID:21266350] ARG30012 Myc phospho Duos, providing antibodies recognize phosphorylated c-Myc at Ser62 and Thr58, is useful for the scientists in c-Myc related study.
靶点名称: Myc
別名: Phospho Myc antibody; Myc phospho (Thr58) antibody; Myc phospho (Ser62) antibody

CAT.NO. : ARG30012

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Size:

1 pair

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Product Details

内含物

货号	内含物名称	宿主克隆性	反应	应用	包装
ARG51538	anti-Myc phospho (Thr58) antibody	Rabbit pAb	Hu, Ms, Rat	IHC-P, WB	50 μl
ARG51785	anti-Myc phospho (Ser62) antibody	Rabbit pAb	Hu, Ms, Rat	ICC/IF, WB	50 μl

概述

产品描述	c-Myc is a multifunctional nuclear phosphoprotein that plays as a transcription factor to involve in controlling many cellular functions, including cell proliferation, cell growth, and cell differentiation, as well as pathways that regulate genome stability and cell death. Mutations, overexpression, rearrangement and translocation of c-myc have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. Phosphorylation of c-Myc at Ser62 by ERK or CDK kinases transiently increases c-Myc stability; however, phosphorylation of c-Myc at Thr58 by GSK3β triggers dephosphorylation of Ser62 by protein phosphatase 2A (PP2A), it lead to c-Myc ubiquitination by the SCF-Fbw7 E3 ligase and proteasomal degradation. Thus the phosphor-Ser62/Thr58 ratio of c-Myc is one of the important indexes in c-Myc activity and stability study.[PMID:21266350] ARG30012 Myc phospho Duos, providing antibodies recognize phosphorylated c-Myc at Ser62 and Thr58, is useful for the scientists in c-Myc related study.
靶点名称	Myc
別名	Phospho Myc antibody; Myc phospho (Thr58) antibody; Myc phospho (Ser62) antibody

属性

存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

全名	Antibody Duo for Phospho Myc (pS62, pS58)
研究领域	Cancer antibody; Controls and Markers antibody; Developmental Biology antibody; Gene Regulation antibody; Signaling Transduction antibody

检测图片 (5)

ARG51785 anti-Myc phospho (Ser62) antibody WB image
Western blot: 30 µg of HeLa cell lysates untreated or treated with calyculin A (50nM, 30mins). The blots were stained with ARG51785 anti-Myc phospho (Ser62) antibody at 1:500 dilution.
ARG51538 anti-Myc phospho (Thr58) antibody WB image
Western Blot: extracts from HeLa cells stained with anti-c-Myc (phospho Thr58) antibody ARG51538 (Lane 2) and the same antibody preincubated with blocking peptide (Lane1).
ARG51785 anti-Myc phospho (Ser62) antibody WB image
Western Blot: extracts from K562 cells, treated with calf intestinal phosphatase (CIP), stained with anti-c-Myc (phospho Ser62) antibody ARG51785.
ARG51538 anti-Myc phospho (Thr58) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-c-Myc (phospho Thr58) antibody ARG51538 (left) or the same antibody preincubated with blocking peptide (right).
ARG51785 anti-Myc phospho (Ser62) antibody ICC/IF image
Immunofluorescence: methanol-fixed HeLa cells stained with anti-c-Myc (phospho Ser62) antibody ARG51785.

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